DIVERSIFICAÇÃO DA PRODUÇÃO RURAL COM O CULTIVO DE FLORES DE CORTE NA REGIÃO DO ALTO VALE DO ITAJAÍ, SC

A floricultura brasileira se caracteriza como um dos mais promissores segmentos da horticultura, gerando grande contingente de empregos e alta rentabilidade por área. A base produtiva da floricultura brasileira é o cultivo em pequenas áreas, contribuído fortemente no desenvolvimento de pequenas propriedades rurais. Neste contexto, o objetivo desse trabalho foi avaliar a qualidade das hastes florais de três flores de corte (sete cultivares de gladíolo, duas de statice e uma de girassol) na região do Alto Vale do Itajaí, SC e divulgar para a comunidade acadêmica e geral as ações de pesquisa e extensão realizados. Os trabalhos foram realizados em cinco propriedades rurais da região do Alto Vale do Itajaí, sendo quatro com girassol e uma com statice e gladíolo. Nas propriedades foram realizados a implantação, acompanhamento e avaliação do cultivo das flores. O experimento foi conduzido no segundo semestre de 2021 para gladíolo e statice e primeiro de 2022 para o girassol. Nas flores foram avaliados os atributos de comprimento e diâmetro total das hastes, além do número de perfilhos e corimbos por haste em statice. Também foi realizado um seminário virtual para divulgação dos resultados à comunidade. Todas as cultivares de gladíolo apresentaram hastes de padrão comercial com comprimento e diâmetro médio de 110 cm e 0,8 cm, respectivamente. O girassol apresentou boa adaptação em todos os quatro municípios avaliados com comprimento e diâmetro da haste superior a 1,25 m e 1,08 cm, respectivamente, conferindo excelente qualidade comercial. A cultivar de statice QIS Yellow apresentou maior comprimento de haste (56,22 cm) e número de perfilhos por hastes (4,01), enquanto a QIS Purple apresentou maior diâmetro de haste (5,3 mm). O seminário foi intitulado: “Flores de corte – renda e diversificação na produção rural” e foi totalmente online com transmissão ao vivo pelo canal do PET Agroecologia no YouTube. No evento foram apresentadas palestras sobre as três flores de corte e os principais resultados das pesquisas realizadas, além do relato de experiência do cultivo destas espécies por uma das produtoras rurais acompanhadas durante os trabalhos de pesquisa on farm. Na transmissão teve-se a presença de estudantes da instituição dos cursos de agronomia, técnico em agroecologia e agropecuária, docentes, técnicos da área, produtores rurais, além da comunidade em geral, totalizando 603 visualizações. Toda organização, apresentação, divulgação e transmissão do evento foi realizado pelos estudantes do curso de Agronomia e do grupo PET Agroecologia Rural Sustentável. O evento exigiu dos estudantes e demais envolvidos desenvolver habilidades de organização, simplificação da informação, uma vez que tempo utilizado para este tipo de evento é reduzido. Permitiu aos estudantes e a instituição a prática da extensão, por meio da inovação, junto à comunidade. Além disso, os resultados indicam que é possível o cultivo de statice, girassol e gladíolo de corte com produção de hastes com qualidade comercial na região do Alto Vale do Itajaí, sendo uma alternativa viável, especialmente aos pequenos produtores rurais.Suporte financeiro Ed. 12/2021/IFC - Campus Rio do Sul

Práticas extensionistas e pesquisa do ensino superior à distância: uma análise acerca dos Cursos de Administração de Vitória da Conquista – BA

Este artigo discute a pesquisa e a extensão realizadas nas instituições EaD de Vitória da Conquista - BA. EaD é a modalidade de educação mediada por tecnologias de informação e comunicação, em que os discentes e docentes estão separados fisicamente no espaço ou temporalmente, ou seja, não estão presentes em um ambiente presencial de ensino-aprendizagem. Essa prática surgiu a partir da necessidade de pessoas que não têm tempo para frequentar um estabelecimento de ensino presencial. A pesquisa realizada é de caráter descritivo e, para sua realização, foi utilizada uma metodologia quantitativa. Trata-se a amostragem por saturação, quando o fechamento amostral se deu por exaustão, quanto ao instrumento, foi aplicado um questionário fechado

Novel Machado-Joseph disease-modifying genes and pathways identified by whole-exome sequencing

Machado-Joseph disease (MJD/SCA3) is a neurodegenerative polyglutamine disorder exhibiting a wide spectrum of phenotypes. The abnormal size of the (CAG)n at ATXN3 explains ~55% of the age at onset variance, suggesting the involvement of other factors, namely genetic modifiers, whose identification remains limited. Our aim was to find novel genetic modifiers, analyse their epistatic effects and identify disease-modifying pathways contributing to MJD variable expressivity. We performed whole-exome sequencing in a discovery sample of four age at onset concordant and four discordant first-degree relative pairs of Azorean patients, to identify candidate variants which genotypes differed for each discordant pair but were shared in each concordant pair. Variants identified by this approach were then tested in an independent multi-origin cohort of 282 MJD patients. Whole-exome sequencing identified 233 candidate variants, from which 82 variants in 53 genes were prioritized for downstream analysis. Eighteen disease-modifying pathways were identified; two of the most enriched pathways were relevant for the nervous system, namely the neuregulin signaling and the agrin interactions at neuromuscular junction. Variants at PARD3, NFKB1, CHD5, ACTG1, CFAP57, DLGAP2, ITGB1, DIDO1 and CERS4 modulate age at onset in MJD, with those identified in CFAP57, ACTG1 and DIDO1 showing consistent effects across cohorts of different geographical origins. Network analyses of the nine novel MJD modifiers highlighted several important molecular interactions, including genes/proteins previously related with MJD pathogenesis, namely between ACTG1/APOE and VCP/ITGB1. We describe novel pathways, modifiers, and their interaction partners, providing a broad molecular portrait of age at onset modulation to be further exploited as new disease-modifying targets for MJD and related diseases

Recomendações e Consensos do Grupo de Estudos de Esclerose Múltipla e da Sociedade Portuguesa de Neurorradiologia sobre Ressonância Magnética na Esclerose Múltipla na Prática Clínica: Parte 1

Magnetic resonance imaging is established as a recognizable tool in the diagnosis and monitoring of multiple sclerosis patients. In the present, among multiple sclerosis centers, there are different magnetic resonance imaging sequences and protocols used to study multiple sclerosis that may hamper the optimal use of magnetic resonance imaging in multiple sclerosis. In this context, the Group of Studies of Multiple Sclerosis and the Portuguese Society of Neuroradiology, after a joint discussion, appointed a committee of experts to create recommendations adapted to the national reality on the use of magnetic resonance imaging in multiple sclerosis. The purpose of this document is to publish the first Portuguese consensus recommendations on the use of magnetic resonance imaging in multiple sclerosis in clinical practice.This work had a investigational grant from Roche Farmaceutica Quimica LDA: EPAM129844-G.info:eu-repo/semantics/publishedVersio

Novel Machado-Joseph disease-modifying genes and pathways identified by whole-exome sequencing

Funding Information: This work was funded by FEDER - Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 - Operacional Programme for Competitiveness and Internationalisation (POCI), Portugal 2020 , and by Portuguese funds through FCT - Fundação para a Ciência e a Tecnologia / Ministério da Ciência, Tecnologia e Ensino Superior in the framework of the project PTDC/DTP-PIC/2638/2017 ( POCI-01-0145-FEDER-016592 ); GenomePT ( POCI-01-0145-FEDER-022184 ); ICVS Scientific Microscopy Platform , member of the national infrastructure PPBI - Portuguese Platform of Bioimaging ( PPBI-POCI-01-0145-FEDER-022122 ; by National funds , through the Foundation for Science and Technology (FCT) - project UIDB/50026/2020 and UIDP/50026/2020 ; and by the project NORTE-01-0145-FEDER-000013 , supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) . MR is supported by FCT ( CEECIND/03018/2018 ). ARVM ( SFRH/BD/129547/2017 ) and AFF ( SFRH/BD/121101/2016 ) are supported by a PhD grant financed by FCT . CB is supported by the Multiple System Atrophy Trust and Alzheimer's Research UK . MDC received funding from National Ataxia Foundation (NAF) and from FCT ( SFRH/BPD/101925/2014 ); DV-C received a grant from FCT ( SFRH/BD/147826/2019 ). Publisher Copyright: © 2021Machado-Joseph disease (MJD/SCA3) is a neurodegenerative polyglutamine disorder exhibiting a wide spectrum of phenotypes. The abnormal size of the (CAG)n at ATXN3 explains ~55% of the age at onset variance, suggesting the involvement of other factors, namely genetic modifiers, whose identification remains limited. Our aim was to find novel genetic modifiers, analyse their epistatic effects and identify disease-modifying pathways contributing to MJD variable expressivity. We performed whole-exome sequencing in a discovery sample of four age at onset concordant and four discordant first-degree relative pairs of Azorean patients, to identify candidate variants which genotypes differed for each discordant pair but were shared in each concordant pair. Variants identified by this approach were then tested in an independent multi-origin cohort of 282 MJD patients. Whole-exome sequencing identified 233 candidate variants, from which 82 variants in 53 genes were prioritized for downstream analysis. Eighteen disease-modifying pathways were identified; two of the most enriched pathways were relevant for the nervous system, namely the neuregulin signaling and the agrin interactions at neuromuscular junction. Variants at PARD3, NFKB1, CHD5, ACTG1, CFAP57, DLGAP2, ITGB1, DIDO1 and CERS4 modulate age at onset in MJD, with those identified in CFAP57, ACTG1 and DIDO1 showing consistent effects across cohorts of different geographical origins. Network analyses of the nine novel MJD modifiers highlighted several important molecular interactions, including genes/proteins previously related with MJD pathogenesis, namely between ACTG1/APOE and VCP/ITGB1. We describe novel pathways, modifiers, and their interaction partners, providing a broad molecular portrait of age at onset modulation to be further exploited as new disease-modifying targets for MJD and related diseases.publishersversionpublishe

MAMMALS IN PORTUGAL : A data set of terrestrial, volant, and marine mammal occurrences in P ortugal

Mammals are threatened worldwide, with 26% of all species being includedin the IUCN threatened categories. This overall pattern is primarily associatedwith habitat loss or degradation, and human persecution for terrestrial mam-mals, and pollution, open net fishing, climate change, and prey depletion formarine mammals. Mammals play a key role in maintaining ecosystems func-tionality and resilience, and therefore information on their distribution is cru-cial to delineate and support conservation actions. MAMMALS INPORTUGAL is a publicly available data set compiling unpublishedgeoreferenced occurrence records of 92 terrestrial, volant, and marine mam-mals in mainland Portugal and archipelagos of the Azores and Madeira thatincludes 105,026 data entries between 1873 and 2021 (72% of the data occur-ring in 2000 and 2021). The methods used to collect the data were: live obser-vations/captures (43%), sign surveys (35%), camera trapping (16%),bioacoustics surveys (4%) and radiotracking, and inquiries that represent lessthan 1% of the records. The data set includes 13 types of records: (1) burrowsjsoil moundsjtunnel, (2) capture, (3) colony, (4) dead animaljhairjskullsjjaws, (5) genetic confirmation, (6) inquiries, (7) observation of live animal (8),observation in shelters, (9) photo trappingjvideo, (10) predators dietjpelletsjpine cones/nuts, (11) scatjtrackjditch, (12) telemetry and (13) vocalizationjecholocation. The spatial uncertainty of most records ranges between 0 and100 m (76%). Rodentia (n=31,573) has the highest number of records followedby Chiroptera (n=18,857), Carnivora (n=18,594), Lagomorpha (n=17,496),Cetartiodactyla (n=11,568) and Eulipotyphla (n=7008). The data setincludes records of species classified by the IUCN as threatened(e.g.,Oryctolagus cuniculus[n=12,159],Monachus monachus[n=1,512],andLynx pardinus[n=197]). We believe that this data set may stimulate thepublication of other European countries data sets that would certainly contrib-ute to ecology and conservation-related research, and therefore assisting onthe development of more accurate and tailored conservation managementstrategies for each species. There are no copyright restrictions; please cite thisdata paper when the data are used in publications.info:eu-repo/semantics/publishedVersio

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio